Dictionary!

• Collagen: Is made of a triple helical alpha domain and has three different alpha domains. It is a triple helix of Gly-X-Y repeats. Collagen is usually found in connective tissue and the skin. This enables the flexibility of the skin. It can help tissues and skin withstand the pressure of pulling without breaking. Collagen is composed of amino acids which include oxygen, carbon, and hydrogen. 

         Collagen has specific amino acids like glycine, proline, hydroxyproline and arginine.

• Laminins: They are heterotrimeric proteins that contain an alpha, beta, and a gamma chain. The proteins intersect to form a cross-like structure. This can bind to the cell membrane and the extracellular molecules. They can bind to cell membranes and contribute to the cell attachment and differentiation. This enables the organs and tissues in body to be held together. 

          Laminins can bind to each other and to other proteins.

• Integrins: These are transmembrane receptors that are able to bridge together cells with other cells and cells with the extracellular matrix. What ligand in the extracellular matrix the integrin can bind to is usually based on the alpha and beta subunits. They can trigger chemical pathways as well. They are obligate heterodimers that have alpha and beta subunits. They also help define cell shape, mobility, and help in the regulation of the cell cycle. The cell’s will be unable to move as it should and function normally. Cell will be unable to reach wherever it needs to go and therefore unable to perform normally.

          When integrins are unable to work properly, they disable the cell shape and structure to work   

                                                                         properly.                                                                     

                                                                 Works Cited Page:

http://www.sigmaaldrich.com/technical-documents/articles/biofiles/laminin.html

http://www.dermoaroma.com/collagen/

http://amdbook.org/content/figure-3-alpha-and-beta-subunits-integrins-are-transmembrane-proteins

http://www.ncbi.nlm.nih.gov/books/NBK21582/

http://www.ncbi.nlm.nih.gov/pubmed/23057746

http://www.ncbi.nlm.nih.gov/books/NBK26867/